| DOE P 203.1 Chg. 1 (AdminChg) | Use of Generative Artificial Intelligence | Current | IM - Office of the Chief Information Officer | Dec 29, 2025 |
| DOE P 226.2PDF | Policy for Federal Oversight and Contractor Assurance Systems | Current | EH - Office of Environment, Health, Safety and Security, MA - Office of Management | Aug 9, 2016 |
| DOE P 310.1 Admin Chg 1PDF | Maximum Entry and Mandatory Separation Ages for Certain Security Employees | Current | HC - Office of the Chief Human Capital Officer | Oct 11, 2001 |
| DOE P 364.1PDF | Health and Safety Training Reciprocity | Current | EH - Office of Environment, Health, Safety and Security | Apr 14, 2014 |
| DOE P 410.3, Chg 1 (Admin Chg)PDF | Program Management | Current | CF - Office of the Chief Financial Officer | Sep 23, 2021 |
| DOE P 411.2C | DOE Scientific Integrity Policy | Current | SC - Office of Science | Jul 24, 2025 |
| DOE P 420.1PDF | Department of Energy Nuclear Safety Policy | Current | EH - Office of Environment, Health, Safety and Security | Feb 8, 2011 |
| DOE P 434.1BPDF | Conduct and Approval of Select Agent and Toxin Work at Department of Energy Sites | Current | EH - Office of Environment, Health, Safety and Security | Nov 25, 2016 |
| DOE P 444.1 Chg. 1 (AdminChg) | Preventing and Responding to all Forms of Violence in the Workplace | Current | HC - Office of the Chief Human Capital Officer | Nov 6, 2014 |
| DOE P 450.4A Chg 1 (MinChg)PDF | Integrated Safety Management Policy | Current | EH - Office of Environment, Health, Safety and Security | Apr 25, 2011 |
| DOE P 451.1PDF | National Environmental Policy Act Compliance Program | Current | GC - Office of General Counsel | Dec 21, 2017 |
| DOE P 454.1 Chg 1 (Admin Chg)PDF | Use of Institutional Controls | Current | EH - Office of Environment, Health, Safety and Security | Apr 9, 2003 |
| DOE P 456.1 Chg 1 (AdminChg)PDF | Secretarial Policy Statement on Nanoscale Safety | Current | EH - Office of Environment, Health, Safety and Security | Sep 15, 2015 |
| DOE P 470.1BPDF | Safeguards and Security Program | Current | EH - Office of Environment, Health, Safety and Security | Feb 10, 2016 |
| DOE P 481.1PDF | DOE's Policy Regarding Laboratories, Plants and Sites Engaging in Strategic Partnership Projects with Other Federal Agencies, Independent Organizations, and the Private Sector | Current | MA - Office of Management | Dec 17, 2014 |
| DOE P 482.2 Chg 1 (AdminChg)PDF | Laboratory Technology Transfer Data Collection and Management | Current | TT - Office of Technology Transitions | Jan 11, 2021 |
| DOE P 485.1APDF | Foreign Engagements with DOE National Laboratories | Current | SC - Office of Science | Dec 13, 2019 |
| DOE P 547.1APDF | Small Business First Policy | Current | SB - Office of Small and Disadvantaged Business Utilization | Mar 30, 2018 |