| DOE P 251.1PDF | Directives System Policy | Archive | ME - Office of Management, Budget and Evaluation/Chief Financial Officer | Mar 19, 1996 |
| DOE P 251.1APDF | Departmental Directives Program Policy | Archive | MA - Office of Management | Aug 16, 2006 |
| DOE P 310.1PDF | Maximum Entry and Mandatory Separation Ages for Certain Security Employees | Archive | HC - Office of the Chief Human Capital Officer | Oct 11, 2001 |
| DOE P 310.1 Admin Chg 1PDF | Maximum Entry and Mandatory Separation Ages for Certain Security Employees | Current | HC - Office of the Chief Human Capital Officer | Oct 11, 2001 |
| DOE P 364.1PDF | Health and Safety Training Reciprocity | Current | EH - Office of Environment, Health, Safety and Security | Apr 14, 2014 |
| DOE P 410.1PDF | Policy Statement on Developing Nuclear Safety Requirements | Archive | EH - Office of Environment, Safety and Health | Sep 29, 1995 |
| DOE P 410.1APDF | Promulgating Nuclear Safety Requirements | Archive | HS - Office of Health, Safety and Security | May 15, 1996 |
| DOE P 410.3PDF | Program Management | Archive | CF - Office of the Chief Financial Officer | Sep 23, 2021 |
| DOE P 410.3, Chg 1 (Admin Chg)PDF | Program Management | Current | CF - Office of the Chief Financial Officer | Sep 23, 2021 |
| DOE P 411.1PDF | Safety Management Functions, Responsibilities, and Authorities Policy | Archive | HS - Office of Health, Safety and Security | Jan 28, 1997 |
| DOE P 411.2PDF | Secretarial Policy Statement on Scientific Integrity | Archive | SC - Office of Science | Jun 2, 2014 |
| DOE P 411.2APDF | DOE Scientific Integrity Policy | Archive | SC - Office of Science | Jan 4, 2017 |
| DOE P 411.2BPDF | DOE Scientific Integrity Policy | Archive | SC - Office of Science | Jan 19, 2024 |
| DOE P 411.2B, Chg 1 (Admin Chg)PDF | DOE Scientific Integrity Policy | Archive | SC - Office of Science | Jan 19, 2024 |
| DOE P 411.2C | DOE Scientific Integrity Policy | Current | SC - Office of Science | Jul 24, 2025 |
| DOE P 413.1PDF | Program and Project Management Policy for the Planning, Programming, Budgeting, and Acquisition of Capital Assets | Archive | MA - Office of Management | Jun 10, 2000 |
| DOE P 413.2PDF | Value Engineering | Archive | MA - Office of Management | Jan 7, 2004 |
| DOE P 420.1PDF | Department of Energy Nuclear Safety Policy | Current | EH - Office of Environment, Health, Safety and Security | Feb 8, 2011 |
| DOE P 426.1PDF | Federal Technical Capability Policy for Defense Nuclear Facilities | Archive | HS - Office of Health, Safety and Security | Dec 10, 1998 |
| DOE P 430.1PDF | Land and Facility Use Planning | Archive | MA - Office of Management | Jul 9, 1996 |
| DOE P 434.1PDF | Conduct and Approval of Select Agent and Toxin Work at Department of Energy Sites | Archive | HS - Office of Health, Safety and Security | Jun 5, 2009 |
| DOE P 434.1APDF | Conduct and Approval of Select Agent and Toxin Work at Department of Energy Sites | Archive | HS - Office of Health, Safety and Security | Nov 7, 2013 |
| DOE P 434.1BPDF | Conduct and Approval of Select Agent and Toxin Work at Department of Energy Sites | Current | EH - Office of Environment, Health, Safety and Security | Nov 25, 2016 |
| DOE P 441.1PDF | DOE Radiological Health and Safety Policy | Archive | HS - Office of Health, Safety and Security | Apr 26, 1996 |
| DOE P 442.1PDF | Differing Professional Opinions on Technical Issues | Archive | HS - Office of Health, Safety and Security | Nov 16, 2006 |