| DOE O 435.1 Chg 2 (AdminChg)PDF | Radioactive Waste Management | Current | EM - Office of Environmental Management | Jul 9, 1999 |
| DOE O 437.1BPDF | Bridge and Tunnel Management | Current | MA - Office of Management | Aug 5, 2026 |
| DOE O 438.1 | Securing the Bulk-Power System | Current | CR - Office of Cybersecurity, Energy Security, and Emergency Response | Jan 15, 2021 |
| DOE O 440.1B Chg 4 (AdminChg)PDF | Worker Protection Program for DOE (Including the National Nuclear Security Administration) Federal Employees | Current | EH - Office of Environment, Health, Safety and Security | May 17, 2007 |
| DOE O 440.2DPDF | Aviation Management and Safety | Current | MA - Office of Management | Aug 5, 2026 |
| DOE O 442.1BPDF | Department of Energy Employee Concerns Program | Current | EH - Office of Environment, Health, Safety and Security | Jan 31, 2019 |
| DOE O 443.1DPDF | Protection of Human Research Subjects | Current | SC - Office of Science | Aug 5, 2026 |
| DOE O 450.2, Chg 1 (MinChg)PDF | Integrated Safety Management | Current | EH - Office of Environment, Health, Safety and Security | Apr 25, 2011 |
| DOE O 452.1GPDF | Nuclear Explosive and Weapon Surety Program | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 452.2GPDF | Nuclear Explosive Safety | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 452.3APDF | Management of the Department of Energy Nuclear Security Enterprise | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 452.4EPDF | Security and Use Control of Nuclear Explosives and Nuclear Weapons | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 452.6BPDF | Nuclear Weapon Surety Interface with the Department of Defense | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 452.7APDF | Protection of Use Control Vulnerabilities and Designs | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 452.8APDF | Control of Nuclear Weapon Data | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 456.1BPDF | The Safe Handling of Unbound Engineered Nanoparticles | Current | EH - Office of Environment, Health, Safety and Security | Aug 5, 2026 |
| DOE O 457.1BPDF | Nuclear Counterterrorism | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 458.1, Chg 5 (Admin Chg)PDF | Radiation Protection of the Public and the Environment | Current | EH - Office of Environment, Health, Safety and Security | Feb 11, 2011 |
| DOE O 460.1D Chg 1 (LtdChg)PDF | Hazardous Materials Packaging and Transportation Safety | Current | EM - Office of Environmental Management | Dec 20, 2016 |
| DOE O 460.2CPDF | Departmental Materials Transportation Management | Current | EM - Office of Environmental Management | Aug 5, 2026 |
| DOE O 461.1DPDF | Packaging and Transportation for Offsite Shipment of Materials of National Security Interest | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 461.2APDF | Onsite Packaging and Transfer of Materials of National Security Interest | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 462.1APDF | Import and Export of Category 1 and 2 Radioactive Sources Aggregated Quantities | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 470.3C Chg 2 (LtdChg)PDF | Design Basis Threat (DBT) | Current | EH - Office of Environment, Health, Safety and Security | Nov 23, 2016 |
| DOE O 470.5A | Insider Threat Program | Current | EH - Office of Environment, Health, Safety and Security | Dec 6, 2024 |