| DOE O 452.4BPDF | Security and Use Control of Nuclear Explosives and Nuclear Weapons | Archive | NA - National Nuclear Security Administration | Jan 22, 2010 |
| DOE O 452.4CPDF | Security and Use Control of Nuclear Explosives and Nuclear Weapons | Archive | NA - National Nuclear Security Administration | Aug 28, 2015 |
| DOE O 452.4DPDF | Security and Use Control of Nuclear Explosives and Nuclear Weapons | Archive | NA - National Nuclear Security Administration | May 20, 2024 |
| DOE O 452.4EPDF | Security and Use Control of Nuclear Explosives and Nuclear Weapons | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 452.6PDF | Nuclear Weapon Surety Interface with the Department of Defense | Archive | NA - National Nuclear Security Administration | Oct 19, 2006 |
| DOE O 452.6APDF | Nuclear Weapon Surety Interface with the Department of Defense | Archive | NA - National Nuclear Security Administration | Apr 14, 2009 |
| DOE O 452.6A Chg 1 (AdminChg)PDF | Nuclear Weapon Surety Interface with the Department of Defense | Archive | NA - National Nuclear Security Administration | Apr 14, 2009 |
| DOE O 452.6BPDF | Nuclear Weapon Surety Interface with the Department of Defense | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 452.7PDF | Protection of Use Control Vulnerabilities and Designs | Archive | NA - National Nuclear Security Administration | May 14, 2010 |
| DOE O 452.7 (Cert Memo)PDF | Certification for DOE O 452.7 | Archive | MA - Office of Management | Jan 15, 2015 |
| DOE O 452.7 Chg 1 (AdminChg)PDF | Protection of Use Control Vulnerabilities and Designs | Archive | NA - National Nuclear Security Administration | May 14, 2010 |
| DOE O 452.7APDF | Protection of Use Control Vulnerabilities and Designs | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 452.8PDF | Control of Nuclear Weapon Data | Archive | NA - National Nuclear Security Administration | Jul 21, 2011 |
| DOE O 452.8APDF | Control of Nuclear Weapon Data | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 456.1PDF | The Safe Handling of Unbound Engineered Nanoparticles | Archive | HS - Office of Health, Safety and Security | May 31, 2011 |
| DOE O 456.1 Admin Chg 1PDF | The Safe Handling of Unbound Engineered Nanoparticles | Archive | HS - Office of Health, Safety and Security | May 31, 2011 |
| DOE O 456.1APDF | The Safe Handling of Unbound Engineered Nanoparticles | Archive | EH - Office of Environment, Health, Safety and Security | Jul 15, 2016 |
| DOE O 456.1APDF | The Safe Handling of Unbound Engineered Nanoparticles | Archive | AU - Office of Environment, Health, Safety and Security | Feb 1, 2016 |
| DOE O 456.1BPDF | The Safe Handling of Unbound Engineered Nanoparticles | Current | EH - Office of Environment, Health, Safety and Security | Aug 5, 2026 |
| DOE O 457.1PDF | Nuclear Counterterrorism | Archive | NA - National Nuclear Security Administration | Feb 7, 2006 |
| DOE O 457.1APDF | Nuclear Counterterrorism | Archive | NA - National Nuclear Security Administration | Aug 26, 2013 |
| DOE O 457.1BPDF | Nuclear Counterterrorism | Current | NA - National Nuclear Security Administration | Aug 5, 2026 |
| DOE O 458.1PDF | Radiation Protection of the Public and the Environment | Archive | HS - Office of Health, Safety and Security | Feb 11, 2011 |
| DOE O 458.1 Admin Chg 1PDF | Radiation Protection of the Public and the Environment | Archive | HS - Office of Health, Safety and Security | Feb 11, 2011 |
| DOE O 458.1 Chg 2PDF | Radiation Protection of the Public and the Environment | Archive | HS - Office of Health, Safety and Security | Jun 6, 2011 |