| DOE G 440.1-7A, Chg 1 (Admin Chg) | Implementation Guide for use with 10 CFR Part 850, Chronic Beryllium Disease Prevention Program | Current | EH - Office of Environment, Health, Safety and Security | Jan 4, 2001 |
| DOE P 410.3, Chg 1 (Admin Chg)PDF | Program Management | Current | CF - Office of the Chief Financial Officer | Sep 23, 2021 |
| DOE G 341.1-1A, Chg 1 (Admin Chg) | Guide on Federal Employee Occupational Medical Programs | Current | HC - Office of the Chief Human Capital Officer | Oct 18, 2007 |
| DOE O 333.1 Chg 2 (AdminChg) | Administering Work Force Discipline, Adverse and Performance Based Actions | Current | HC - Office of the Chief Human Capital Officer | May 14, 2015 |
| DOE O 314.1A, Chg 1 (AdminChg) | Telework and Remote Work Program | Current | HC - Office of the Chief Human Capital Officer | Oct 13, 2023 |
| DOE N 251.128 | Cancellation of DOE O 436.1A, Departmental Sustainability and DOE O 311.1B Chg. 1 (LtdChg), Equal Employment Opportunity and Diversity Program | Current | MA - Office of Management | Jan 30, 2025 |
| DOE O 224.3A Chg 2 (LtdChg) | Audit Coordination, Resolution, and Follow-up | Current | CF - Office of the Chief Financial Officer | Oct 22, 2020 |
| DOE O 200.2A | Information Collection Management Program | Current | IM - Office of the Chief Information Officer | Jan 19, 2025 |
| DOE O 515.1PDF | Advisory Committee Management Program | Current | AB - Office of Secretarial Boards and Councils | Jan 16, 2025 |
| DOE O 100.1E Chg 5 (LtdChg)PDF | Secretarial Succession, Threat Level Notification, and Successor Tracking | Current | NA - National Nuclear Security Administration | Jan 17, 2025 |
| DOE O 414.1EPDF | Quality Assurance | Archive | EH - Office of Environment, Health, Safety and Security | Dec 18, 2024 |
| DOE O 470.4CPDF | Safeguards and Security Planning | Archive | EH - Office of Environment, Health, Safety and Security | Dec 18, 2024 |
| DOE O 470.1APDF | Safeguards and Security Program Operations Management | Archive | EH - Office of Environment, Health, Safety and Security | Dec 18, 2024 |
| DOE O 443.1C Chg. 1 (LtdChg)PDF | Protection of Human Research Subjects | Archive | SC - Office of Science | Nov 26, 2019 |
| DOE O 470.5A | Insider Threat Program | Current | EH - Office of Environment, Health, Safety and Security | Dec 6, 2024 |
| DOE O 251.1E Chg. 1 (LtdChg) | Departmental Directives Program | Current | MA - Office of Management | Dec 18, 2024 |
| DOE O 224.3A Chg. 1 (LtdChg)PDF | Audit Coordination, Resolution, and Follow-Up | Archive | CF - Office of the Chief Financial Officer | Oct 22, 2024 |
| DOE O 137.1B Chg. 3 (LtdChg)PDF | Operating in the Event of a Lapse of Appropriations | Current | CF - Office of the Chief Financial Officer | Sep 30, 2011 |
| DOE O 130.1A Chg. 1 (LtdChg)PDF | Budget Planning, Formulation, Execution and Departmental Performance Management | Archive | CF - Office of the Chief Financial Officer | Jan 7, 2021 |
| DOE O 520.1B Chg 2 (LtdChg)PDF | Financial Management and Chief Financial Officer Responsibilities | Archive | CF - Office of the Chief Financial Officer | Jan 7, 2021 |
| DOE P 120.1PDF | Energy and Environmental Justice Policy | Archive | EJE - Office of Energy Justice and Equity | Nov 26, 2024 |
| DOE O 203.1APDF | Limited Personal Use of Government Office Equipment including Information Technology | Archive | IM - Office of the Chief Information Officer | Nov 23, 2024 |
| DOE N 251.127 | Cancellation of DOE N 435.1, Contact-Handled and Remote-Handled Transuranic Waste Package | Current | MA - Office of Management | Aug 20, 2024 |
| DOE O 522.1A Chg. 1 (LtdChg)PDF | Pricing of Departmental Materials and Services | Archive | CF - Office of the Chief Financial Officer | Aug 2, 2018 |
| DOE O 241.1CPDF | Scientific and Technical Information Management | Archive | SC - Office of Science | Oct 28, 2024 |